Steroids and derivatives
Medchemexpress LLC (S)-N-((3-Methyl-1-(methyl-d3)-1H-pyrazol-4-yl)sulfonyl)-6-(3-(3,3,3-trifluoro-2,2-dimethylpropoxy)-1H-pyrazol-1-yl)-2-(2,2,4-trimethylpyrrolidin-1-yl)nicotinamide | 2216712-66-0 | 99.23% | 600.67 | 500 UG
Elexacaftor-d3 (VX-445-d3) is the deuterium labeled form of Elexacaftor, designed as a tracer and internal standard for quantitative analysis using methods like NMR, GC-MS, or LC-MS. Deuterium substitution can impact the pharmacokinetic and metabolic profiles of drugs. Elexacaftor (VX-445) is a next-generation cystic fibrosis transmembrane conductance regulator (CFTR) corrector, which helps restore Phe508del CFTR protein function and has potential in treating cystic fibrosis. When combined with Tezacaftor and VX-770, it significantly enhances Phe508del CFTR protein processing, trafficking, and chloride transport.
- Tracer and internal standard for quantitative analysis
- Potential to influence pharmacokinetic and metabolic profiles of drugs
- Restores Phe508del CFTR protein function
- Potential to treat cystic fibrosis
- Enhances CFTR protein processing, trafficking, and chloride transport
Medchemexpress LLC Cyclin D2/CCND2 Antibody (YA789) | Predicted band size: 33 kDa; Observed band size: 38 kDa | 100 UL
The Cyclin D2/CCND2 Antibody (YA789) is a Mouse-derived, non-conjugated IgG2b monoclonal antibody designed to target Cyclin D2/CCND2. It is suitable for use in Western Blot (WB) applications.
- Mouse-derived
- Monoclonal antibody
- Reacts with human samples
- Supplied in 1x PBS, 50% glycerol, 0.5% BSA, and 0.02% sodium azide
- Recommended storage at -20°C for up to one year
- Affinity purified
- Non-conjugated
- Isotype IgG2b
Medchemexpress LLC 3-O-Methyldopa-d3 hydrate | 300-48-1 | 232.25 | 1 MG
3-O-Methyldopa-d3 (hydrate) is the deuterium labeled 3-O-Methyldopa. 3-O-Methyldopa (3-Methoxy-L-tyrosine) hydrate is a metabolite of L-DOPA that can cross the blood-brain barrier (BBB). 3-O-Methyldopa hydrate inhibits the astrocyte-mediated protective effect of L-DOPA on dopaminergic neurons. In addition, 3-O-Methyldopa hydrate has certain antidepressant and neuroprotective activities. 3-O-Methyldopa hydrate can be used in the research of nervous system diseases such as depression and Parkinson's disease.
- This compound can be used as a tracer.
- This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Enzo Life Sciences 25(OH) Vitamin D Controls (1Set)
25(OH) Vitamin D Controls for use with 25(OH) Vitamin D ELISA Kit. Content: 1 high and 1 low control. Long Term Storage: -80°C. Applications: ELISA .
Medchemexpress LLC Cyclin D2/CCND2 antibody (YA789) | Affinity purified | Predicted band size: 33 kDa; Observed band size: 38 kDa | 10 UL
Cyclin D2/CCND2 antibody (YA789) is a mouse-derived, non-conjugated IgG2b monoclonal antibody targeting Cyclin D2/CCND2. It is formulated in 1x PBS (pH 7.3), 50% glycerol, and 0.5% BSA, containing 0.02% sodium azide as a preservative. This antibody is intended for research use only and reacts with human species.
- Host: Mouse
- Clonality: Monoclonal
- Isotype: IgG2b
- Species reactivity: Human
- Purity: Affinity purified
- Applications: Western Blot (WB)
- Immunogen: Synthetic peptide corresponding to human Cyclin D2
- Storage: Store at -20°C for 1 year, avoid repeated freeze/thaw cycles
Medchemexpress LLC Rufinamide-d2 | 1129491-38-8 | C10H6D2F2N4O | 1 MG
Rufinamide-d2 (CGP 33101-d2) is a deuterium-labeled Rufinamide, an orally active antiepileptic compound. It inhibits Na+ current activation and neuronal hyperexcitability, exhibiting anticonvulsant effects. This compound is utilized in the study of Lennox-Gastaut syndrome, with its deuteration influencing pharmacokinetic and metabolic profiles.
- Inhibits Na+ current activation
- Inhibits neuronal hyperexcitability
- Provides anticonvulsant effects
- Used in the study of Lennox-Gastaut syndrome
- Deuterium-labeled for tracer applications
- Influences pharmacokinetic and metabolic profiles
[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@H](CC[C@]4(C)[C@H]3CC[C@]12C)OC(=O)NCCCN(C)C | 5mg | 779524214](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502467785.JPG-250.jpg)
eMolecules 184582-91-0 | DMPAC-Chol | Broadpharm514.839 | C33H58N2O2 | 0.000 | CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@H](CC[C@]4(C)[C@H]3CC[C@]12C)OC(=O)NCCCN(C)C | 5mg | 779524214
DMPAC-Chol | Broadpharm | 184582-91-0514.839 | C33H58N2O2 | 0.000 | CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@H](CC[C@]4(C)[C@H]3CC[C@]12C)OC(=O)NCCCN(C)C | 5mg | 779524214
Medchemexpress LLC N-Caproicacid-d3 so 5mg
N-caproicacidsodiumsalt-d3 is the deuterium labeled N-caproicacidsodiumsalt[1]
Medchemexpress LLC Dopamine D2 receptor antagonist-1 | 1055411-77-2 | 99.1% | 1 ML
Dopamine D2 receptor antagonist-1 is a negative allosteric modulator (NAM) of the dopamine D2 receptor (D2R) with sub-mM affinity.
- Acts as a negative allosteric modulator
- Targets the dopamine D2 receptor (D2R)
- Exhibits sub-mM affinity
Cayman Chemical 6-MethylmercaptopurIn-d3 10mg
An internal standard for the quantification of 6-MMP by GC- or LC-MS
eMolecules 6147-11-1 | ??-mangostin | Ambeed | MFCD00135200 | 410.466 | C24H26O6 | 98.000 | COc1c(O)cc2oc3cc(O)c(CC=C(C)C)c(O)c3c(=O)c2c1CC=C(C)C | 1mg | 761012452
??-mangostin | Ambeed | 6147-11-1 | MFCD00135200 | 410.466 | C24H26O6 | 98.000 | COc1c(O)cc2oc3cc(O)c(CC=C(C)C)c(O)c3c(=O)c2c1CC=C(C)C | 1mg | 761012452
Cambridge Isotope Laboratories 2 4-Dinitrotoluene (ring-D3 98%) 1 mg/mL in acetonitrile-D3 1 mL
2 4-Dinitrotoluene (ring-D3 98%) 1 mg/mL in acetonitrile-D3 1 mL
Medchemexpress LLC Betaine-d3 chloride | 1219349-47-9 | 156.63 | 1 MG
Betaine-d3 (chloride) is a deuterium-labeled version of Betaine chloride. It is intended for research use only and not for sale to patients. Stable heavy isotopes, such as deuterium, are incorporated into drug molecules primarily as tracers for quantitative analysis during drug development, and deuterium substitution can influence the pharmacokinetic and metabolic profiles of drugs.
- Deuterium labeled Betaine chloride.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Purity: 98.63%.
Medchemexpress LLC Ramelteon-d3 | 1432057-38-9 | 99.0% | C16H18D3NO2 | 1 MG
Ramelteon-d3 (TAK-375-d3) is a deuterium-labelled Ramelteon, a potent and highly selective agonist of MT1/MT2 receptors. It has potential for insomnia research, consistently reducing sleep onset without residual effects or withdrawal symptoms. This compound can be used as a tracer and as an internal standard for quantitative analysis, with deuteration potentially affecting pharmacokinetic and metabolic profiles of drugs.
- Deuterium-labelled Ramelteon
- Agonist of MT1/MT2 receptors
- Reduces sleep onset without residual effects
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS